If you've just got back from leave and got an inbox of 100s of e-mails you should use this one next time;
I'm out the office until ..
The server has not stored your email. This means you will now need to resend it on my return if it needs my attention.
Your e-mail has not been forwarded.
Then set a rule up to archive/delete everything whilst you're away. Of course you may get lots of incoming mail on your return but 8/10 will have been sorted and wont require your attention.